Medically the evaluation by Darren Hein, PharmD — created by college of Illinois — updated on September 2, 2018


Mucinex and Nyquil Cold & Flu space two common, over-the-counter remedies you can discover on your pharmacist’s shelf. Compare the symptoms that each medicine treats as well as their side effects, interactions, and warnings to watch if one is a better option for you.

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The main differences between these drugs space their active ingredients and how those work-related to treat her symptoms.

Mucinex treats chest congestion. The main energetic ingredient is one expectorant called guaifenesin. It functions by thinning the consistency of mucus in her air passages. This i m going up mucus in your chest for this reason you have the right to cough the up and also out.

NyQuil temporary treats common cold and flu symptoms such together fever, cough, nasal congestion, young aches and also pains, headache, and also runny nose and sneezing. The active ingredients are acetaminophen, dextromethorphan, and doxylamine. This ingredients each work a little differently.

For example, paracetamol is a pains reliever and also fever reducer. It alters the method your body senses pain and also regulates temperature. Dextromethorphan suppresses the signal in your brain that cause your coughing reflex. Doxylamine, top top the other hand, block a problem in her body referred to as histamine. This substance causes allergy symptoms such as itchy, watery eyes, runny nose, and also itchy nose or throat. Together, these ingredients provide the relief friend can get from NyQuil.

The following table summarizes the differences between Mucinex and also NyQuil at a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, sleep congestion, minor aches and pains, headache, sick throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, oral granulesoral liquid capsule, oral solution
Risk the interactionsnoyes
Risk of severe side effectsnoyes

*There is likewise an extra-strength type of this tablet, which has twice as lot of the active ingredient.

Forms and dosage

You have the right to use Mucinex throughout the day, but you frequently use NyQuil at night to assist you sleep and also let your body recover. The ingredient doxylamine in NyQuil likewise causes drowsiness to help you get rest.

Mucinex and also NyQuil Cold & Flu are just for people 12 years and older. However, NyQuil has actually other products that are specifically made for children ages 4 come 11 years.

The encourage dosage for each medicine varies follow to the form. Monitor the encourage dosage ~ above the package of whatever form you choose. You will should ask your doctor for the correct dosage that NyQuil to provide to youngsters who are 4 come 11 year old.

Mucinex walk not have actually the danger of severe side effects. However, the adhering to serious side results may be feasible with NyQuil:

vision problems, such together blurry visiondifficulty urinatingallergic reaction, v symptoms together as:red, peeling or blistering skinrashhivesitchingswelling that the face, throat, tongue, lips, eyes, hands, or lower legsdifficulty breathing or swallowing

If you have actually serious next effects, you have to stop utilizing the drug and also call her doctor.


Drug interactions have the right to increase or decrease the impact of the other medications. Interactions can likewise increase your threat of next effects. There are no known far-reaching interactions v guaifenesin, the energetic ingredient in Mucinex. However, all three energetic ingredients of NyQuil interact with various other drugs.

Acetaminophen can interact with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can connect with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can communicate with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such as fentanyl, hydrocodone, methadone, and also morphine

You shouldn’t use Mucinex or NyQuil to treat a long-term cough. Utilizing too much can reason harmful effects. You additionally shouldn’t use these assets to treat symptoms of any type of medical condition you have without talking to your medical professional first.

Other conditions

Other conditions you may have can impact how NyQuil functions for you. In part conditions, this drug have the right to be harmful. Asking a doctor before using NyQuil if girlfriend have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t use Mucinex or NyQuil for much longer than seven days. If your symptoms no relieved after ~ a week, call your doctor and stop using these drugs.

NyQuil contains acetaminophen, which have the right to cause far-ranging liver damages if girlfriend overuse it. Taking much more than 4 doses the NyQuil in 24 hours can reason severe liver damage. Countless over-the-counter drugs also contain acetaminophen. If you take NyQuil, make sure you don’t take it it with other drugs the contain acetaminophen. This will assist make sure you nothing accidentally use too lot of the drug.

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Mucinex and also NyQuil room both commodities that relieve symptoms of the common cold or flu. The symptoms they treat space different. You have the right to take Mucinex and also NyQuil together safely if you monitor the recommended dosage for each drug. However, acquisition Mucinex at night with NyQuil might actually store you native falling asleep. Mucinex will loosen your mucus, which can cause you to wake approximately cough.

Deciding between the two might simply mean picking the drug that treats the symptoms that are bothering girlfriend the most. The course, you must never take any type of drug if you’re no sure just how to use it or if it’s ideal for you. Always talk come your doctor if you have questions.